简介：Thesympatheticnervoussystemplaysacardinalroleinregulatingcardiacfunctionthroughreleasingtheneurotransmitternorepinephrine(NE).Incomparisonwithcentralnervoussystem,themolecularmechanismofNEuptakeinmyocardiumisnotclear.Inpresentstudy,weprovedthatinrattheCNStypeofNEtransporter(NET)wasalsoexpressedinmiddlecervical-stellateganglioncomplex(MC-SGcomplex)whichisconsideredtocontroltheactivityofheart,butnotexpressedinmyocardium.TheresultsalsoshowedthatNETexpressionlevelinrightganglionwassignificantlyhigherthanintheleft,renderingthegreatercapacityofNEuptakeinrightventricle,afactwhichmaycontributetothemaintenanceofrightventricularfunctionunderpathologicstate.

简介：<正>Althoughapoptosishasbeenrecentlydocumentedtotransmitimmunosuppressivesignals,theirsignificanceinallogeneictransplantationhasnotbeenreported.Inthepresentstudy,weinvestigatedtheinfluenceofdonorapoptoticsplenocytesonallograftsurvivalinaSDtoWistarratcardiactransplantmodel.Donorsplenocyteswereisolatedandirradiatedwithultraviolet(UV)toinduceapoptosisinvitro.5x107apoptotic,necroticoruntreateddonorspleencellsweretransfusedpreoperativelyandcardiacallogeneictransplantation