简介：AIM:Tosystematicallyreviewwhethertheincreasedfluctuationofintraocularpressure(IOP)isariskfactorforopenangleglaucoma(OAG)progression.METHODS:ScientificstudiesrelevanttoIOPfluctuationandglaucomaprogressionwereretrievedfromMEDLINE,EMBASEandCENTRALdatabases,andwerelistedasreferencesinthispaper.Thehazardratio(HR)wascalculatedbyusingfixedorrandom-effectsmodelsaccordingtotheheterogeneityofincludedstudies.RESULTS:Individualdatafor2211eyesof2637OAGpatientsinfourteenprospectivestudieswereincludedinthisMeta-analysis.Allstudieswerelongitudinalclinicalstudieswithfollow-upperiodrangingfrom3to8.5y.ThecombinedHRwas1.23(95%CI1.04-1.46,P=0.02)fortheassociationbetweenIOPfluctuationandglaucomaonsetorprogressionwiththeevidenceofheterogeneity(P<0.1).SubgroupanalyseswithdifferenttypesofIOPfluctuationwerealsoevaluated.ResultsindicatedthatthesummaryHRwas0.98(95%CI0.78-1.24)inshort-termIOPfluctuationgroup,whichshowednostatisticalsignificancewithheterogeneity,whereas,thecombinedHRwas1.43(95%CI1.13-1.82,P=0.003)inlong-termIOPfluctuationgroupwithouthomogeneity.SensitivityanalysisfurthershowedthatthepooledHRwas1.10(95%CI1.03-1.18,P=0.004)forlong-termIOPfluctuationandvisualfunctionprogressionwithhomogeneityamongstudies(P=0.3).CONCLUSION:Long-termIOPfluctuationcanbeariskfactorforglaucomaprogressionbasedonthepresentedevidence.Thus,controllingtheswingofIOPiscrucialforglaucomaorglaucomasuspectingpatients.