学科分类
/ 1
1 个结果
  • 简介:Epithelialovariancancer(EOC)istheleadingcauseofdeathamongallgynecologicalmalignancies.Despitethetechnologicalandmedicaladvancesoverthepastfourdecades,suchasthedevelopmentofseveralbiologicalmarkers(mRNAandproteinsbiomarkers),themortalityrateofovariancancerremainsachallengebecauseofitslatediagnosis,whichisspecificallyattributedtolowspecificitiesandsensitivities.Underthiscompulsivescenario,recentadvancesinexpressionbiologyhaveshiftedinidentifyinganddevelopingspecificandsensitivebiomarkers,suchasmicroRNAs(miRNAs)forcancerdiagnosisandprognosis.MiRNAsareanovelclassofsmallnon-codingRNAsthatderegulategeneexpressionattheposttranscriptionallevel,eitherbytranslationalrepressionorbymRNAdegradation.Thesemechanismsmaybeinvolvedinacomplexcascadeofcellulareventsassociatedwiththepathophysiologyofmanytypesofcancer.MiRNAsareeasilydetectableintissueandbloodsamplesofcancerpatients.Therefore,miRNAsholdgoodpromiseaspotentialbiomarkersinovariancancer.Inthisreview,weattemptedtoprovideacomprehensiveprofileofkeymiRNAsinvolvedinovariancarcinomatoestablishmiRNAsasmorereliablenon-invasiveclinicalbiomarkersforearlydetectionofovariancancercomparedwithproteinandDNAbiomarkers.

  • 标签: 生物标志物 肿瘤诊断 卵巢癌 预后 MIRNAS 开发