简介：　　【摘要】 目的：了解美托洛尔联合曲美他嗪对冠心病合并心衰患者心功能的影响。方法：选取 2017年 5月 -2019年 5月笔者所在医院收治的 128例冠心病合并心衰患者，依据不同治疗方法分为两组，治疗组 64例予以美托洛尔联合曲美他嗪治疗，对照组 64例予以常规药物治疗，观察比较两组临床疗效、心功能指标改善。结果：治疗组治疗总有效率为 95.31%，高于对照组的 78.13%，比较差异有统计学意义（ P<0.05）；治疗后，治疗组 LEVDD、 LVEF、 LVESD等心功能指标水平均优于对照组 ,比较差异均有统计学意义（ P<0.05）。结论：临床采用美托洛尔联合曲美他嗪治疗对冠心病合并心衰治疗，可在提升治疗效果的基础上 ,促进心功能改善，推荐临床应用。  　　【关键词】 美托洛尔； 曲美他嗪； 冠心病合并心衰； 心功能  　 Objective: To investigate the effect of metoprolol combined with trimetazidine on cardiac function in patients with coronary heart disease and heart failure. Methods: 128 patients with coronary heart disease complicated with heart failure in our hospital from May 2017 to may 2019 were selected and divided into two groups according to different treatment methods. 64 cases in the treatment group were treated with metoprolol combined with trimetazidine, while 64 cases in the control group were given conventional drug treatment. The clinical efficacy and cardiac function indexes of the two groups were observed and compared. Results: the total effective rate of the treatment group was 95.31%, higher than 78.13% of the control group, the difference was statistically significant (P < 0.05); after treatment, the levels of levdd, LVEF, LVESD and other cardiac function indexes in the treatment group were better than those in the control group, and the differences were statistically significant (P < 0.05). Conclusion: metoprolol combined with trimetazidine in the treatment of coronary heart disease complicated with heart failure can promote the improvement of cardiac function on the basis of improving the therapeutic effect, which is recommended for clinical application.