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简介：摘要目的探究泮托拉唑长期用于治疗老年人反流性食管炎的临床疗效.方法随机选取我院２０１０年１０月~２０１２年１０月间收治的老年人反流性食管炎患者１４０例,分为对照组和治疗组,每组７０例,对照组患者连续服用２个月泮托拉唑,４０mg/次,２次/d.治疗组患者连续服用１年泮托拉唑,４０mg/次,１次/d.在第２个月时对所有患者的临床症状及治愈情况进行分析比较.在第６个月和第１２个月时,给予对照组随访调查,给予治疗组临床症状、治愈情况进行观察分析.分析比较两组患者的临床症状及复发情况.结果治疗２个月时,对照组症状缓解的总有效率为９１．４％,对照组患者症状缓解的总有效率为８２．９％;第６个月时,治疗组患者症状缓解的总有效率为８４．６％,对照组患者症状缓解的总有效率为４８．６％;第１２个月时,治疗组患者症状缓解的总有效率为８８．５％;对照组患者症状缓解的总有效率为３７．１％.两组患者在短期内均疗效显著,但从长期疗效看,治疗组患者的总有效率明显高于对照组,对比具有统计学意义(p＜０．０５)．结论长期服用泮托拉唑疗治老年人反流性食管炎,既可以有效的控制其复发率,还具有良好的疗效,值得推广应用.关键词泮托拉唑;老年人;反流性食管炎;长期疗效AbstractObjectiveToexplorethelong－termclinicalefficacyofpantoprazolefortreatingrefluxesophagitisintheelderly．Methodsrandomlyselectedinourhospitalin２０１０toOctober２０１２inOctoberwereelderlyreverseflowofesophagitisin１４０patientswith,dividedintotreatmentgroupandcontrolgroup,７０casesineachgroup,patientsinthecontrolgrouptaking２monthsofpantoprazole,４０mg/time,２timesdaily．Thepatientsinthetreatmentgroupweretakenfor１years,pantoprazole,４０mg/times,１times/d．Theclinicalsymptomsandcureofallpatientswereanalyzedinsecondmonths．Atsixthmonthsandtwelfthmonths,thecontrolgroupwasgivenafollow－upinvestigation,andtheclinicalsymptomsandcureofthetreatmentgroupwereobservedandanalyzed．ThecliniＧcalsymptomsandrecurrenceofthetwogroupswereanalyzedandcompared．Resultsthetotaleffectiveratewas２inthecontrolgroupand８２．９％inthecontrolgroup．Thetotaleffectiveratewassixthinthetreatmentgroupand４８．６％inthecontrolgroup．Thetotaleffectiveratewastwelfthinthecontrolgroupand３７．１％inthecontrolgroup．Thetotaleffectiveratewas８８．５％．Twogroupsofpatientsintheshorttermhassignificanteffect,butfromthelong－termefficacyoftreatmentgrouptotalefficiencywassignificantlyhigherthanthatofthecontrolgroup,comparedwithstatisticalsignificance(P＜０．０５)．Conclusionlong－termuseofpantoprazolehealingelderlyrefluxesophagitiscaneffectivelycontroltherecurrencerate,alsohasgoodcurativeeffect,itisworthyofpopularizationandapＧplicatioKney．wordsPantoprazole;Elderly;Refluxesophagitis;Longtermeffect中图分类号R９１４文献标识码B文章编号１００１－５３０２(２０１５)０９－０６７２－０１