简介：摘要目的探讨２型糖尿病患者基础血糖波动与微血管病变的关系.方法对２６２例２型糖尿病住院患者,采用稳态模式评价胰岛素抵抗.根据微血管病变数量分为无微血管病变组、１种微血管病变组、２种微血管病变组和３种微血管病变组.依据微血管病变数量、不同时间血糖曲线下面积进行分析.结果随着微血管病变数目增多,空腹血糖、尿白蛋白排泄率、收缩压、舒张压、体重指数和餐前血糖曲线下面积呈升高趋势(P＜０??０５).Logistic分析显示舒张压和早餐前血糖曲线下面积是影响所有２型糖尿病患者微血管病变独立的危险因素.结论２型糖尿病患者微血管病变的发生发展可能与早餐前血糖波动密切相关.关键词２型糖尿病;基础血糖;微血管疾病AbstractObjectiveTostudythepatientswithtype２diabetesmellitusbloodglucosefluctuationandtherelationshipbetweenthemicrovascularlesion??Methods２６２casesofhospitalizedpatientswithtype２diabetes,thesteady－statemodelassessmentofinsulinresistance??AccordingtothenumberofmicrovasＧcularlesioncanbedividedintonomicrovascularlesiongroup,onekindofmicrovascularlesiongroup,thetwokindsofmicrovascularlesiongroupandthreekindsofmicrovascularlesiongroup??Bloodsugaraccordingtomicrovascularlesionnumber,thedifferenttimeareaunderthecurvewereanalyzed??ResultswithmicroＧvascularlesionnumberincrease,fastingbloodsugar,urinealbuminexcretionrate,systolicpressure,diastolicbloodpressure,bodymassindexandbloodsugarbeforemealareaundercurveshowedatrendofincrease(P＜０??０５)??Logisticanalysisshowedthatthediastolicbloodpressureandglucoseafterbreakfastareaunderthecurveisaffectallindependentriskfactorsinpatientswithtype２diabetesmicrovascularlesions??Conclusioninpatientswithtype２diabetesmaybereＧlatedtKoetyhewoorcdcsurrenceofmicrovascularlesiondevelopmentiscloselyrelatedtothebloodglucosefluctuationsafterbreakfast??Diabetesmellitus,type２;Bloodglucose;Microangiopathy中图分类号R５８７文献标识码A文章编号１００８－６３１５(２０１５)１２－０７３２－０２