Phase Transfer Catalyzed Synthesis and Antibacterial Activity of Water-soluble S-Triazolo[3,4-b][1,3,4]thiadiazoles Containing Piperazine Group-中国期刊网

摘要 6/3-(4-Chlorophenyl)-s-triazolo[3,4-b][1,3,4]thiadiazoles(2a-e)and(5a-e)weresynthesizedrespectivelybyintermolecularcyclizationof5-aryl/4-chlorophenyl-4-amino-3-mercapto-1,2,4-triazoles(1a-e)and(4)with4-chlorobenzoicacid/arylacids,whichwerecondensedwithpiperazineunderphasetransfercatalystTBABtoyieldthecorrespondingfreebasesofmonopiperazinederivativesandfollowedtoformwater-solublesalts(3a-e)and(6a-e)withhydrochloricacidingoodyields.Theinvitrobiologicalresultsshowedthatpiperazinegroupconjugatedwiththeabovefusedheterocyclesplayedanimportantroleinantibacterialactivity.ThestructuresofnovelcompoundswereconfirmedbyIR,1HNMR,MSandelementalanalysis.

1Guo. Synthesis and antitumor evaluation of C3/C3 fluoroquinolone dimers (I): Tethered with a fused heterocyclic s-triazolo[2,1-b][1,3,4]thiadiazole.化学,2010-06.
2ZOUKai-huang;ZHANGLi-xue;ZHANGAn-jiang;LEIXin-xiang;HUANGHui-hua;ZHANGZi-yi. Preparation and Crystal Structure of 3-（2-Hydroxyphenyl） -6- （4-nitrophenyl）-7H- 1,2,4-triazolo[3,4-b][1, 3,4]thiadiazine.化学,2005-01.
3Jie Zhao Bao Quan Chen Yan Ping Shi Yu Ming Liu Hai Chuan Zhao Ji Cheng. Synthesis and in vitro antitumor activity of 1,3,4-thiadiazole derivatives based on benzisoselenazolone.化学,2012-07.
4Saad Moulay Fatima M＇zyéne. SYNTHESIS OF SOLUBLE POLY（3,4-DIHYDROXY-o-TOLYLENE）： REDOX POLYMER.高分子化学,2006-01.
5ZHANG，Yan;WANG，Qin;等. Synthesis and Antibacterial Activities of 4—Amino—3—（1—aryl—5—methyl—1,2,3—triazol—4—yl）—5—mercapto—1,2,4—triazoles／2—Amino—5—（1—aryl—5—methyl—1,2,3—triazol—4—yl）—1,3,4—.化学,2002-02.
6MENG, L;LIU, JF. Synthesis and characterization of trisubstituted heteropolytungstogermanates containing group 3A elements.化学,1995-04.
7Vadim V. Annenkov;Uma Maheswari Krishnan;Viktor A. Pal'shin;Stanislav N. Zelinskiy;Gayathri Kandasamy;Elena N. Danilovtseva. Bioinspired Water-soluble Polymers with Grafted Polyamine Chains： Synthesis and Complexation with Oligonucleotides.高分子化学,2018-10.
8Fu, Yile Wang, Lanying Zhang, Xianghan Lu, Tianqin Xie, Qianjie Shi, Zhen. Synthesis and Spectral Properties of Novel Water-soluble Indocyanine Dyes as Fluorescent Dyes for Proteins Detection.化学,2011-03.
9BAO Xiangjun;HONG Ruibin;HU Jianhua;ZHONG Yiping;LIU Ping;DENG Wenji. Preparation and Properties of Water-soluble Conjugated Polyelectrolyte.材料科学与工程,2014-04.
10Y.Mansoori;S.Shah Sanaei;S.V.Atghia;M.R.Zamanloo;Gh.Imanzadeh. SYNTHESIS OF ORGANO SOLUBLE AROMATIC POLY（AMIDE-IMIDE）S BASED ON 2-（5-（3,5-DINITROPHENYL）-1,3,4-OXADIAZOLE-2-YL）PYRIDINE IN AN IONIC LIQUID.高分子化学,2011-06.

Phase Transfer Catalyzed Synthesis and Antibacterial Activity of Water-soluble S-Triazolo[3,4-b][1,3,4]thiadiazoles Containing Piperazine Group

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Phase Transfer Catalyzed Synthesis and Antibacterial Activity of Water-soluble S-Triazolo[3,4-b][1,3,4]thiadiazoles Containing Piperazine Group

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