A Mitochondrial Genome Sequence of the Tibetan Antelope （ Pantholops hodgsonii ）-中国期刊网

摘要 ToinvestigategeneticmechanismsofhighaltitudeadaptationsofnativemammalsontheTibetanPlateau,wecomparedmitochondrialsequencesoftheendangeredPantholopshodgsoniiwithitslowlanddistantrelativesOvisariesandCaprahircus,aswellasothermammals.ThecompletemitochondrialgenomeofP.hodgsonii(16,498bp)revealedasimilargeneorderasofothermammals.Becauseoftandemduplications,thecontrolregionofP.hodgsoniimitochondrialgenomeisshorterthanthoseofO.ariesandC.hircus,butlongerthanthoseofBosspecies.PhylogeneticanalysisbasedonalignmentsoftheentirecytochromebgenessuggestedthatP.hodgsoniiismorecloselyrelatedtoO.ariesandC.hircus,ratherthantospeciesoftheAntilopinaesubfamily.TheestimateddivergencetimebetweenP.hodgsoniiandO.ariesisabout2.25millionyearsago.FurtheranalysisonnaturalselectionindicatedthattheCOXI(cytochromecoxidasesubunitI)genewasunderpositiveselectioninP.hodgsoniiandBosgrunniens.Consideringthesameclimatesandenvironmentssharedbythesetwomammalianspecies,weproposedthatthemitochondrialCOXIgeneisprobablyrelevantforthesenativemammalstoadaptthehighaltitudeenvironmentuniquetotheTibetanPlateau.

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A Mitochondrial Genome Sequence of the Tibetan Antelope （ Pantholops hodgsonii ）

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A Mitochondrial Genome Sequence of the Tibetan Antelope （ Pantholops hodgsonii ）

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