Point mutation of 5＇ noncoding region of BCL-6 gene in primary gastric lymphomas-中国期刊网

摘要 AIM:Toinvestigatethemutationsofthe5'noncodingregionofBCL-6geneinChinesepatientswithprimarygastriclymphomas.METHODS:PCRanddirectDNAsequencingwereusedtoidentifyBCL-6genemutationsinthe5'noncodingregionin29casesofgastricdiffuselargeB-celllymphoma(DLBCL)and18casesofgastricmucosa-associatedlymphoidtissue(MALT)lymphomaaswellas10casesofreactivehyperplasiaoflymphnode(LRH).RESULTS:Sixof29gastricDLBCLs(20.7%),4of18gastricMALTlymphomas(22.2%)and1of10LRHs(10%)werefoundtohavemutations.Allmutationsweresingle-basesubstitutionsandthefrequencyofsingle-basechangeswas0.20x10-2-1.02x10-2perbp.CONCLUSION:Pointmutationsinthe5'noncodingregionofBCL-6genearefoundinChinesepatientswithprimarygastricDLBCLsandMALTlymphomas,suggestingthattheymay,insomeextent,participateinthepathogenesisofprimarygastricDLBCLsandMALTlymphomas.

1向直富;卢玉英;赖永榕;陈燕;李慧玉;邹萍. Bcl-2 GENE REARRANGEMENT DETERMINED BY PCR AS AMEAN TO DETECT MINIMAL RESIDUAL DISEASE INMALIGNANT LYMPHOMAS.肿瘤,1999-01.
2肖华亮;王东;李增鹏;牟江洪. Detection of apoptotic cells and immunohistochemical study of bcl-2 and p53 gene protein in primary gastric mucosa-associated lymphoid tissue (MALT) lymphoma.肿瘤,2000-03.
3TAOQINHUA;JINGYANG;等. Cloning and analysing of 5‘ flanking region of Xenopus organizer gene noggin.细胞生物学,1999-03.
4XuChang-tai;GuoXue-gan;PanBoRong. Gene therapy in gastric cancer.消化系统,2003-06.
5谢建兰,滕孝静,郑媛媛,张燕林,周小鸽. 原发心脏大B细胞淋巴瘤MYC、bcl-2、bcl-6基因转位及EB病毒检测.医药卫生,2021-07.
6Yun-Hao Chen;Hui-Ying Xu;Zhang-Yang Wang;Zhe-Hui Zhu;Cheng-Di Li;Zhi-Gang Wu;Bi-Cheng Chen. An insertion mutation in the androgen receptor gene in a patient with azoospermia.泌尿科学,2015-05.
7张贺龙;王文亮;崔大祥. DETECTION OF GENE MUTATION IN SPUTUM OF LUNG CANCER PATIENT.肿瘤,1999-01.
8CHANG Liang;ZHONG Su;ZHAO Nan;LIU Ping;ZHAO Yangyu;QIAO Jie. APPLICATION OF GENETIC DEAFNESS GENE CHIP FOR DETECTION OF GENE MUTATION OF DEAFNESS IN PREGNANT WOMEN.耳鼻咽喉科,2014-02.
9申霞,周露婷,李安琪,易红梅,欧阳斌燊,许海敏,谢嘉玲,顾怡瑾,张蕾,董磊. 伴有MYC、bcl-2和/或bcl-6重排的高级别B细胞淋巴瘤临床病理学特征.医药卫生,2022-12.
10Chen Liu;Guangbing Li;Rongrong Chen;Xiaobo Yang;Xue Zhao;Haitao Zhao. A novel PTEN gene promoter mutation and untypical Cowden syndrome.肿瘤,2013-03.

Point mutation of 5＇ noncoding region of BCL-6 gene in primary gastric lymphomas

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Point mutation of 5＇ noncoding region of BCL-6 gene in primary gastric lymphomas

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