The IAP family：endogenous caspase inhibitors with multiple biological activities-中国期刊网

摘要 IAPs(inhibitorsofapoptosis)areafamilyofproteinscontainingoneormorecharacteristicBIRdomains.Theseproteinshavemultiplebiologicalactivitiesthatincludebindingandinhibitingcaspases,regulatingcellcycleprogression,andmodulatingreceptor-mediatedsignaltransduction.OurrecentstudiesfoundtheIAPfamilymembersXIAPandc-IAP1areubiquitinatedanddegradedinproteasomesinresponsetoapoptoticstimuliinTcells,andtheirdegradationappearstobeimportantforTcellstocommittodeath.InadditiontothreeBIRdomains,eachoftheseIAPsalsocontainsaRINGfingerdomain.Wefoundthisregionconfersubiquitinproteaseligase(E3)activitytoIAPs,andisresponsiblefortheauto-ubiquitinationanddegradationofIAPsafteranapoptoticstimulus.GiventhefactthatIAPscanbindavarietyofproteins,suchascaspasesandTRAFs,itwillbeofinteresttocharacterizepotentialsubstratesoftheE3activityofIAPsandtheeffectsofubiquitinationbyIAPsonsignaltransduction,cellcycle,andapoptosis.

1Liu Ji-hua Liu Ji-ping Lu Dan Wang En-si Li Ping-ya. Studies on the Structural modification of ginsenosides with antitumor biological activities.药学,2008-04.
2Jagdish K. Sahu;Swastika Ganguly;AtulKaushik. Triazoles： A valuable insight into recent developments and biological activities.中药学,2013-05.
3He Yu-Qin,Zhang Zhi-Yao,Zhou Hui-Xing,Ye Fang,Chen Wen-Ming. Competing endogenous RNA network in newly diagnosed multiple myeloma by genetic microarray.医药卫生,2020-11.
4LV Haitao;DUAN Ke;SHAN Hu. Selenylation Modification of Degraded Polysaccharide from Enteromorpha prolifera and Its Biological Activities.海洋科学,2018-02.
5Christopher E Ekpenyong;Ernest Akpan;Azah Nyoh. Ethnopharmacology, phytochemistry, and biological activities of Cymbopogon citratus （DC.） Stapf extracts.中药学,2015-05.
6许良忠;建方方;时建刚;孙萍萍;焦奎. Synthesis, Structure and Biological Activities of Novel Triazole Compounds Containing N,N-Dialkyldithiocarbamate Moiety.化学,2004-07.
7ChaoCHAI FeiYE. Simple, Mild and Convenient Synthesis of Two Novel N-Dichloro-acetyl Oxazolidines and their Biological Activities.化学,2004-10.
8TANGHui＇An;WANGXiaofang;YANGSheng;WANGLiufang. Synthesis, characterization, and biological activities of Pt（Ⅱ） and Pd（Ⅱ）complexes with 2′,3′,4′,5,7-pentahydroxy flavone.金属材料,2004-01.
9. Microwave-assisted Solid-phase Synthesis, Biological Evaluation and Molecular Docking of Angiotensin I-converting Enzyme Inhibitors.化学,2012-01.
10Esra Dereli;E. Gulriz Akaroglu. Factors That Affect Psycho-Social Development of Preschool Children in Terms of Art Activities＂ Family and Teacher of Variables.教育学,2011-01.

The IAP family：endogenous caspase inhibitors with multiple biological activities

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The IAP family：endogenous caspase inhibitors with multiple biological activities

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