摘要
Objective:Cancerisoneofthemostcommondiagnosesinelderlypatients.Ofalltypesofabdominalcancer,colorectalcancer(CRC)isundoubtedlythemostfrequent.Medianageatdiagnosisisapproximately70yearsoldworldwide.Duetothemultiplecomorbiditiesaffectingelderlypeople,frailtyevaluationisveryimportantinordertoavoidover-orundertreatment.Thispilotstudywasdesignedtoinvestigatethevariablescapableofpredictingthelong-termriskofmortalityandlivingsituationaftersurgeryforCRC.Methods:Patientswith70yearsoldandolderundergoingelectivesurgeryforCRCwereprospectivelyenrolledinthestudy.Thepatientswerepreoperativelyscreenedusing11internationally-validated-frailty-assessmenttests.Theendpointsofthestudywerelong-termmortalityandlivingsituation.ThedatawereanalyzedusingunivariateCoxproportional-hazardregressionanalysistoverifythepredictivevalueofscoreindicesinordertoidentifypossibleriskfactors.Results:Forty-sixpatientswerestudied.Themedianfollow-uptimeaftersurgerywas4.6years(range,2.9-5.7years)andnopatientswerelosttofollow-up.Theoverallmortalityratewas39%.Fourofthepatientswhosurvived(4/28,14%)losttheirfunctionalautonomy.ThepreoperativeimpairedTimedUpandGo(TUG),EasternCooperativeGroupPerformanceStatus(ECOGPS),InstrumentalActivitiesofDailyLiving(IADLs),VulnerableEldersSurvey(VES-13)scoringsystemsweresignificantlyassociatedwithincreasedlongtermmortalityrisk.Conclusion:Simplifiedfrailty-assessingtoolsshouldberoutinelyusedinelderlycancerpatientsbeforetreatmentinordertostratifypatientrisk.TheTUG,ECOG-PS,IADLsandVES-13scoringsystemsarepotentiallyabletopredictlong-termmortalityanddisability.Additionalstudieswillbeneededtoconfirmthepreliminarydatainordertoimprovemanagementstrategiesforoncogeriatricsurgicalpatients.
出版日期
2015年04月14日（中国期刊网平台首次上网日期，不代表论文的发表时间）
