摘要
Theacousticstartleresponsehasbeenusedtoevaluatetinnitusandhyperacusisinanimalmodels.Gapinducedprepulseinhibitionoftheacousticstartlereflex(gap-PPI)isaffectedbytinnitusandloudnesschanges.Sincetinnitusandreducedsoundtolerancearecommonlyseeninelderly,wemeasuredgap-PPIinFischer344rats,anagingrelatedhearinglossmodel,atdifferentages:3-5months,9-12months,and15-17months.Thestartleresponsewasinducedbythreedifferentintensityofsound:105,95and85dBSPL.Gap-PPIwasinducedbydifferentdurationofsilentgapsfrom1to100ms.Whenthestartlewasinducedby105dBSPLsoundintensity,thegap-PPIinducedby50mssilentgapwassignificantlylowerthanthoseinducedby25or100msduration,showinga"notch"inthegap-PPIfunction.The"notch"disappearedwiththereductionofstartlesound,suggestingthe"notch"mayberelatedwithhyper-sensitivitytoloudsound.Astheintensityofthestimulusdecreased,theappearanceofthehyperacusis-likeeffectdecreasedmorequicklyfortheyoungestgroupofrats.Wealsotestedscopolamine,amuscarinicacetylcholinereceptorantagonist,andmecamylamine,anicotinicacetylcholinereceptorantagonist,ontheeffectofgap-PPI.Whenscopolaminewasadministered,theresultsindicatednoadditioneffectonthehyperacusis-likephenomenoninthetwooldergroups.Mecamylamine,thenicotinicantagonistalsoshowedeffectsontheappearanceofhyperacusisonratsindifferentages.Theinformationderivedfromthestudywillbefundamentalforthefurtherresearchindeterminingthecauseandtreatmentforhyperacusis.
出版日期
2014年02月12日（中国期刊网平台首次上网日期，不代表论文的发表时间）
