PURGE OF MALIGNANT CELLS FROM BONE MARROW BY HEMATOPORPHYRIN DERIVATIVES AND LIGHT EXPOSURE IN VITRO-中国期刊网

摘要 Duringautologousbonemarrowgraftintreatmentofmalignantdiseases,itiscriticaltopurgemalignantcellsfromthemarrow.Inthepresentstudy,thesensitivitytophotodynamicinactivationof3leukemiccelllineswascomparedwiththeircounterpartnormalhematopoieticcells.AftermouseleukemicL1210cellsweretreatedwithapreparationofhematoporphyrinderivatives,YHpD,10μg/mlfor1hr.andirradiatedwithblacklight(peakwavelength395nm,lightintensity0.6mW/cm2)for5minutes,thesurvivalrateofclonogeniccellsdecreasedto<10%,whilethatofbonemarrowgranulocytemacrophageprogenitorcells(CFU-GM)inDBA/2miceremainedatnearlynormallevel(>80%).SimilarresultswereobtainedwhenhumanleukemicHL-60cellswerecomparedwithhumanCFU-GMandmouseleukemicL615cellswithCFU-GMin615strainmice.ItissuggestedthathematoporphyrinphotoradiationmaybeusefulforIselectivelykillingleukemiccellsinbonemarrow.

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PURGE OF MALIGNANT CELLS FROM BONE MARROW BY HEMATOPORPHYRIN DERIVATIVES AND LIGHT EXPOSURE IN VITRO

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PURGE OF MALIGNANT CELLS FROM BONE MARROW BY HEMATOPORPHYRIN DERIVATIVES AND LIGHT EXPOSURE IN VITRO

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